Simultaneous determination of 24 congeners of 2- and 3-monochloropropanediol esters and 7 congeners of glycidyl esters using direct multi-residue analytical LC-MS/MS methods in various food matrices

Ching-Chang Lee ^a,b, Bo-Lun Lin ^c, Yi-Wen Huang ^a, Ning-Syuan Hsu ^a, Wei-Hsiang Chang ^b,c,*

^a Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan

^b Research Centre of Environmental Trace Toxic Substances, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan

^c Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan

Glycidyl esters (GEs) and 2- and 3-monochloropropanediol esters (MCPDEs) are emerging process-generated food contaminants known as possible carcinogens. Herein, a direct method is developed and validated for the first time to simultaneously quantify seven GEs and twenty-four MCPDE congeners of processed foods using liquid chromatography-tandem mass spectrometry in a single sequence without ester cleavage or derivatisation, thereby allowing for the simultaneous analysis of numerous food matrices with high accuracy and precision. Our results show levels of GEs varying from <LOQ to 13486 ng/g, whereas those of MCPDEs range from <LOQ to 12019 ng/g, respectively.

Keywords: Food matrix, Glycidyl ester, LCMS/MS, 3-MCPD ester, 2-MCPD ester

https://doi.org/10.38212/2224-6614.3442