Comprehensive multiplexed analysis of risky drugs in eggs based on magnetic zeolitic imidazolate frameworks and UHPLC Q-Orbitrap HRMS

Wei Jia*, Yuyang Liu, Xi Xu, Yanxi Zhang, Lin Shi

School of Food and Biological Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China

A novel magnetic adsorbent solid-phase Fe3O4@ZIF-8 extraction method coupled with UHPLC Q-Orbitrap high resolution mass spectrometry for the sensitive and high efficiency detection of fluoroquinolones, tetracyclines, dyes and amphenicols in eggs is described. Under optimum conditions, CCβ and CCα of 0.62 to 26.97 μg.kg–1 and 0.36 to 16.37 μg.kg–1 was obtained, which is much better than that obtained by conventional methods. The accuracy, expressed as recovery, were achieved falling between 75% and 104%. The proposed strategy provides several advantages of simplicity and low energy consumption, thus retaining potential for the screening of risky drugs in various samples.

Keywords: Egg, Magnetic extraction, Matrix effect, Q-Orbitrap, Veterinary drugs

https://doi.org/10.38212/2224-6614.3360

(https://www.jfda-online.com/journal/vol29/iss3/7)