Ultra-sensitive electrochemical sensing of acetaminophen and codeine in biological fluids using CuO/CuFe2O4 nanoparticles as a novel electrocatalyst

Foroozan Hasanpour*, Masoumeh Taei, Somayeh Tahmasebi

Chemistry Department, Payame Noor University, Tehran 19395-3697, Iran

Copper ferritecopper oxide (CuO-CuFe2O4) nanoparticles as a semiconductor composite with pen junction were synthesized by co-precipitation reaction. Then, a novel CuOCuFe2O4 carbon paste modified electrode was fabricated which displays an effectual electrocatalytic response to the oxidation of acetaminophen (AC) and codeine (CO). A linear range of 0.01e1.5 mmol L1 and 0.06-10.0 mmol L1 with the detection limits of 0.007 mmol L1 and 0.01 mmol L1 were achieved for AC and CO, respectively. The practical usage of the proposed sensor revealed reasonable results for quantification of AC and CO in biological fluids.