Sonam Miglani ^a, Rakesh Raman Patyar ^b, Sazal Patyar ^a,*, Mohammad Rafi Reshi ^a

^a Department of Pharmacology, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India
^b Postgraduate Institute of Medical Education and Research, Chandigarh, India

 

Aim of the present study was to assess the hepatoprotective activity of goat milk on antitubercular drug-induced hepatotoxicity in rats. Hepatotoxicity was induced in rats using a combination of isoniazid, rifampicin, and pyrazinamide given orally as a suspension for 30 days. Treatment groups received goat milk along with antitubercular drugs. Liver damage was assessed using biochemical and histological parameters. Administration of goat milk (20 mL/kg) along with antitubercular drugs (Group III) reversed the levels of serum alanine aminotransferase (82 ± 25.1 vs. 128.8 ± 8.9 units/L) and aspartate aminotransferase (174.7 ± 31.5 vs. 296.4 ± 56.4 units/L, p