Ganiyu Oboh ^a,b,*, Opeyemi Babatunde Ogunsuyi ^a,
Mariam Damilola Ogunbadejo ^b, Stephen Adeniyi Adefegha ^a

^a Department of Biochemistry, Federal University of Technology Akure, Akure, Nigeria
^b Department of Biochemistry, Federal University Oye, Oye-Ekiti, Nigeria

 

Acarbose is an antidiabetic drug which acts by inhibiting α-amylase and α-glucosidase activities but with deleterious side effects. Gallic acid (GA) is a phenolic acid that is widespread in plant foods. We therefore investigated the influence of GA on α-amylase and α-glucosidase inhibitory properties of acarbose (in vitro). Aqueous solutions of acarbose and GA were prepared to a final concentration of 25μM each. Thereafter, mixtures of the samples (50% acarbose + 50% GA; 75% acarbose