Journal of Food and Drug Analysis (JFDA)
【Update Date:2022-06-20】unit:
The study of distribution of ingested terbinafine on skin with ambient ionization tandem mass spectrometry
Yi-Tzu Cho a,**, Hung Su b, Ching-Ying Wu c, Jingyueh Jeng d,e, Chi-Wei Lee f, Deng-Chyang Wu g,h,i, Tiao-Lai Huang j,k,***, Jentaie Shiea b,l,m,*
a Department of Cosmetic Applications and Management, Yuh-Ing Junior College of Health Care & Management, Kaohsiung 807634,Taiwan
b Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 804201, Taiwan
c Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan
d Department of Medicinal Chemistry, Chia Nan University of Pharmacy and Science, Tainan 717301, Taiwan
e Department of Cosmetic Science & Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan 717301,Taiwan
f Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
g Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung MedicalUniversity, Kaohsiung 807378, Taiwan
h Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 807378, Taiwan
i Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan
j Department of Psychiatry, Chang Gung Memorial HospitaleKaohsiung Medical Center and Chang Gung University College of Medicine, No. 123, Ta-pei Rd., Niaosung District, Kaohsiung 833401, Taiwan
k Genomic and Proteomic Core Laboratory, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung833401, Taiwan
l Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807378, Taiwan
m Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan
We aim to develop an efficient and non-invasive strategy for monitoring of drugs and their metabolites via human skin. Probe sampling was combined with thermal desorption-electrospray ionization tandem mass spectrometry (TDESI/MS/MS) to characterize trace terbinafine, which was secreted on patient's skin after ingesting terbinafine tablets. The terbinafine ion signals were directly detected in the samples collected from different skin regions and the signals were monitored for 8 weeks. The detection and location of terbinafine via the skin suggest that the methods are useful in rapidly and noninvasively collecting the molecular information of the ingested drug on skin for pharmacokinetic studies.
Keywords: Epidermis, Skin, Terbinafine, Thermal desorption-electrospray ionization tandem mass spectrometry
https://doi.org/10.38212/2224-6614.3413
(https://www.jfda-online.com/journal/vol30/iss2/10/