Pharmacokinetics of panduratin a following oral administration of a Boesenbergia pandurata extract to rats

Jihyun Won ^a, Keumhan Noh ^b, Jae-Kwan Hwang ^c,*, Beom Soo Shin ^d,**, Wonku Kang ^a,***

a College of Pharmacy, Chung-Ang University, Seoul 06974, South Korea

b Deapartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M55 3M2, Canada

c Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea

d School of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea

Boesenbergia pandurata and its major active ingredient, panduratin A (PAN), exhibit antibacterial, anti-oxidant, anti-inflammatory, and anti-obesity effects. We explored the time course of the plasma and tissue (in the major organs, gums and skin) concentrations of PAN after oral administration of a B. pandurata extract to rats. Model-dependent analysis was used to quantify the skin distribution of PAN after systemic exposure. The PAN level peaked at 1.12 ± 0.22 μg/mL after 3 h, and then biexponentially decayed with a terminal half-life of 9 h. The mean clearance (Cl/F) was 2.33 ± 0.68 L/h/kg. The PAN levels in organs were in the following order (highest first): skin, lung, heart, gum, liver, spleen, kidney, and brain. For the first time, the time course of PAN levels in plasma and organs was investigated after oral administration of a BPE. This study helps to explain the pharmacological activities of PAN in the skin and gums. The pharmacokinetic model provided data in the plasma and skin concentrations of PAN, which are of fundamental importance to evaluate its efficacy.

Keywords: BPE, Panduratin A, Pharmacokinetic modeling, Plasma, Skin

https://doi.org/10.38212/2224-6614.3382