Journal of Food and Drug Analysis (JFDA)
【Update Date:2006-02-05】unit:
Department of Pharmacology, School of Medicine, Shandong University, 44 W. Wenhua Rd., Jinan, Shandong 250012, P.R.O.C.
(Received: November 9, 2005; Accepted: March 6, 2006)
Abstract
An increasing number of studies suggest that angiotensin (Ang) II contributes to the pathology of cerebrovascular disease possibly through injuring of the brain microvascular endothelial cells (BMEC), but the mechanisms involved are not well elucidated. Recent studies reveal the importance of Ang II in reactive oxygen species induction and endothelial injury. Hence, the present study investigated the involvement of oxidative stress in Ang II-induced BMEC injury.
Key words: brain microvascular endothelial cell, angiotensin II, AT1 receptor, losartan, oxidative stress