Revisit gut microbiota and its impact on human health and disease

Rui-xue Ding^a , Wei-Rui Goh^b, Ri-na Wu^a, Xi-qing Yue^a, Xue Luo^a, Wei Wei Thwe Khine^b, Jun-ruiWu^a, Yuan-Kun Lee^b

^a College of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China

^b Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Singapore 117597, Singapore

Trillions of microbes have evolved with and continue to live on human beings. With the rapid advances in tools and technology in recent years, new knowledge and insight in cross-talk between the microbes and their hosts have gained. It is the aim of this work to critically review and summarize recent literature reports on the role of microbiota and mechanisms involved in the progress and development of major human diseases, which include obesity, hypertension, cardiovascular disease, diabetes, cancer, Inflammatory Bowel Disease (IBD), gout, depression and arthritis, as well as infant health and longevity.

Keywords: Gut microbiota, Human health, Disease