Collaborative Study on the Determination of Phencyclidine in Urine by Gas Chromatography-Mass Spectrometry
KUEI HUI CHAN1, MEI-CHICH HSU2*, WEI-LAN CHU3, WEN-ING TSAY4 AND CHIAREIY LIU4
1. Graduate Institute of Coaching Science, National Taiwan Sport University, Taoyuan, Taiwan (R.O.C.)
2. Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan, Taiwan (R.O.C.)
3. Division of Clinical Toxicology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (R.O.C.)
4. National Bureau of Controlled Drugs, Department of Health, Executive Yuan, Taipei, Taiwan (R.O.C.)
(Received: August 22, 2008; Accepted: October 6, 2008)
ABSTRACT
A gas chromatography-mass spectrometry method for the analysis of phencyclidine (PCP) in urine was subjected to an interlaboratory study. The collaborative study followed the guidelines provided by the Association of Official Analytical Chemists International. Ten laboratories participated, analyzing 3 samples of PCP-spiked urine as blind duplicate. The repeatability relative standard deviation (RSDr) and the reproducibility relative standard deviation (RSDR) were between 2.1%-3.6% and 4.2%-7.3%, respectively. HORRAT values for the reproducibility showed 0.4-0.7, indicating acceptable precision between laboratories. The method was thus proposed to be used by the drug-abuse urine testing laboratories in Taiwan.
Key words: phencyclidine, GC-MS, urine, inter-laboratory study