Stability-Indicating High-Performance Liquid Chromatographic Assay Methods for Drugs in Pharmaceutical Dosage Forms: Part I
Chih Ho1 and Gan-Lin Chen2
1. National Laboratories of Foods and Drugs, Department of Health, Taipei, Taiwan, R. O. C
2. School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, R.O.C.
ABSTRACT
A review of applications of stability-indicating high-performance liquid chromatographic (HPLC) assay methods for drugs in various pharmaceutical dosage forms is presented. A survey of articles primarily on the significant developments in this field is covered in this paper. Selected substances are grouped to integrate drugs that share similar uses or actions. Papers selected by the authors are briefly summarized, and HPLC systems developed in these papers for stability testing of pharmaceuticals are tabulated to assist readers in selecting an appropriate system for a given pharmaceutical. The information given in the table includes the drug names, materials, column types, mobile-phase compositions, detections, internal standards used and the literature references.
Key words: Pharmaceutical dosage forms, stability-indicating,high-performance liquid chromatography(HPLC)