Quality of Taiwan Pharmaceuticals: Survey of Ampicillin Capsules

YANN-JEN FANN, YU-SHAN LIN, MEI-CHICH HSU* AND CHIA PO LIN

National Laboratories of Foods and Drugs Department of Health, Executive Yuan, Taiwan, R.O.C.
*Graduate Institute of Sports Sciences, National College of Physical Education and Sports, 250 Wen-Hwa lst Road, Kweishan, Taoyuan, Taiwan,R.O.C.

ABSTRACT

   In order to understand the quality of ampicillin capsules, fifty samples (46 domestic, 4 imported) were purchased from different counties and cities in Taiwan during 1991 fiscal year. All of the samples were investigated for appearance, mean weight, weight uniformity, identification of drug, potency, dissolution, content uniformity, and loss on drying. The results showed that 5 samples (10.0%) failed to meet the potency requirement of the official regulation (90-120%) and the contents of uniformity. Besides, there were three samples (6.0%) did not meet the specification of dissolution test.

Key words: Ampicillin, quality, HPLC.