Quantitation of Active Ingredients in Cold Syrup-Collaborative Study

HUI-YEN WU, YI-NI CHENG, MENG-LING CHANG AND YEU-PING LIN

Union Chemical Laboratories, Industrial Technology Research Institute, 321 Kuang Fu Road, Section 2, Hsinchu, Taiwan 30042, R.O.C.

ABSTRACT

   This collaborative study was performed with a high performance liquid chromatography method to determine the active ingredients content in the cold syrup. Eighteen local drug manufacturers' analytical laboratories participated in this study. The testing results were evaluated by using the ranking score and t-test techniques. The ranking score test indicated that none of the laboratories have any pronounced systematic errors, but results from the t-test evaluation indicated that some of the reported data were not within the 95% confidence level. According to the intralaboratory and interlaboratories studies, it has been shown that this analytical method is applicable to the determination of acetaminophen, caffeine and guaifenesin in cold syrup.

Key Words: Collaborative study, Acetaminophen, Caffeine, Guaifenesin