Chemical Constituents and Anti-platelet Aggregation Activity from the Root of Peucedanum formosanum
Yu-Chang Chen1,2, Peng-Yin Chen1, Chin-Chung Wu1, Ian-lih tsai1 and Ih-Sheng Chen1*
1. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung City 807, Taiwan (R.O.C.)
2. School of Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung City 404, Taiwan (R.O.C.)
(Received: July 13, 2007; Accepted: October 8, 2007)
ABSTRACT
Analysis of the root extract of Peucedanum formosanum (Taiwan Qian-Hu) led to the isolation of 32 known compounds. The structures of these isolates were determined by spectral data. Some of them displayed strong anti-platelet aggregation activities. Analysis showed that most of the constituents found in P. formosanum were the same as those found in P. praeruptorum (Bai-Hua Qian-Hu), in that many isolates of both plants’ roots belong to seselin-type dihydropyranocoumarins and psoralen-type furanocoumarins.
Key words: Peucedanum formosanum, Umbelliferae, root, Qian-Hu, furanocoumarin, dihydropyranocoumarin, anti-platelet aggregation