Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: A review
| 發布日期：2016-01-07 | 維護日期：2016-04-12
發布單位：
Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: A review
M.Abd Elgadir a, Md.Salim Uddin b, Sahena Ferdosh c, Aishah Adam a,Ahmed Jalal Khan Chowdhury c, Md.Zaidul Islam Sarker b,*
a Department of Pharmacology and Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Bandar
Puncak Alam, Selangor, Malaysia
b Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia,
Kuantan Campus, 25200 Kuantan, Pahang, Malaysia
c Faculty of Science, International Islamic University Malaysia, Kuantan Campus, 25200 Kuantan, Pahang, Malaysia
Chitosan is a promising biopolymer for drug delivery systems. Because of its beneficial properties, chitosan is widely used in biomedical and pharmaceutical fields. In this review, we summarize the physicochemical and drug delivery properties of chitosan, selected studies on utilization of chitosan and chitosan-based nanoparticle composites in various drug delivery systems, and selected studies on the application of chitosan films in both drug delivery and wound healing. Chitosan is considered the most important polysaccharide for various drug delivery purposes because of its cationic character and primary amino groups, which are responsible for its many properties such as mucoadhesion, controlled drug release, transfection, in situ gelation, and efflux pump inhibitory properties and permeation enhancement. This review can enhance our understanding of drug delivery systems particularly in cases where chitosan drug-loaded nanoparticles are applied.
Keywords: chitosan, drug delivery system, nanoparticle composite, wound healing