Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning

Subham Banerjee a,b, Pronobesh Chattopadhyay a,*, Animesh Ghosh b,
Shiv Sankar Bhattacharya c, Amit Kundu d, Vijay Veer a
a Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur 784 001, Assam, India
b Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, 835 215 Ranchi, Jharkhand, India
c School of Pharmaceutical Sciences, IFTM University, Moradabad 244 001, Uttar Pradesh, India
d Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, West Bengal, India

The current study evaluated the stability potential of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters.

Keywords: Eserine, International Conference on Harmonisation guidelines, Pralidoxime chloride, Stability, Transdermal patch