Cell microenvironment stimuli-responsive controlled-release delivery systems based on mesoporous silica nanoparticles
Chun-Ling Zhu a,*, Xian-Wei Wanga, Zhen-Zhen Lin a, Zeng-Hong Xie a, Xiao-Ru Wangb
a Department of Chemistry, Fuzhou University, Fuzhou, PR China
b Xiamen Huaxia Vocational College, Wenjiao Aera, Jimei Xiamen, Fujian, PR China
To develop novel tumor cell microenvironment stimuli-responsive smart controlledrelease delivery systems is one of the current common interests of materials science and clinical medicine. Meanwhile, mesoporous silica nanoparticles as a promising drug carrier have become the new area of interest in the field of biomedical application in recent years because of their unique characteristics and abilities to efficiently and specifically entrap cargo molecules. This review describes the more recent developments and achievements of mesoporous silica nanoparticles in drug delivery. In particular, we focus on the stimuliresponsive controlled-release systems that are able to respond to tumor cell environmental changes, such as pH, glucose, adenosine-50-triphosphate (ATP), glutathione (GSH), and H2O2.
Keywords: Cell environmentally responsive, mechanisms, Controlled-release delivery system, Mesoporous silica nanoparticles, Stimuli-responsive