NF-κB Inhibitors from Terrestrial Plants Reported in 2011

MARC SCHUMACHER, MARIO DICATO AND MARC DIEDERICH*

Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et Sang, Luxembourg

ABSTRACT

This review shows that more than 40 natural products isolated from terrestrials natural sources in 2011 expressed NF-κB inhibition properties. It has to be pointed that an α,β-unsaturated ketone function was present in more than fifty percent of the reported structures, which might explain the observed bioactivity. Hence, there is still a supply of bioactive products isolated from natural sources. Briefly, this review shows the potential of natural sources as a source for the development of anti-cancer agents.

Key words: Nuclear factor-κB, ketone, bioactivity, cancer