Cytotoxicity, Anti-Platelet Aggregation Assay and Chemical Components Analysis of Thirty-Eight Kinds of Essential Oils
Hsiu-Fang Yen1, Sheng-Yang Wang2, Chin-Chung Wu3, Wan-Yu Lin3,
Tung-Ying Wu3, Fang-Rong Chang3,4 * AND CHIN-KUN WANG1 *
1. School of Nutrition, Chung Shan Medical University, Taichung, Taiwan, R.O.C.
School of Nutrition, Chung Shan Medical University, Taichung, Taiwan, R.O.C.
2. Department of Forestry, National Chung-Hsing University, Taichung, Taiwan , R.O.C.
3. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan , R.O.C.
4. Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan , R.O.C.
(Received: June 26, 2011; Accepted: December 13, 2011)
ABSTRACT
T hirty-eight essential oils (EOs), including 4 products from Taiwan high-latitude trees, Chamaecyparis formosensis, Taiwania cryptomerioides, Cryptomeria japonica, and Chamaecyparis obtuse, as well as 34 commercial essential oils, were assayed on their cytotoxicity against 5 cancer cell lines and anti-platelet aggregation function.
Two EOs from Juniperus virginiana and Santalum album showed significant cytotoxicity. Moreover, 2 EOs from Melissa officinalis and Piper nigrum exhibited moderate inhibitory effects on an anti-platelet aggregation assay. Some essential oils had been reported to contain cytotoxicity. However, the cytotoxicity of EOs from J. virginiana and S. album is revealed for the first time. To the best of our knowledge, this is the first report for anti-platelet aggregation effect of EOs.
Key words:bioactivity, essential oils (EOs), Juniperus virginiana, Santalum album, Melissa officinalis, Piper nigrum