Water-soluble Phenolic Compounds and Their Anti-HIV-1 Activities from the Leaves of Cyclocarya paliurus
JUAN ZHANG1,3, NING HUANG2, JIN-CAI LU3, XU LI1,3, YUN-HUA WANG2,
LIU-MENG YANG2, YONG-TANG ZHENG2,* AND KAI XIAO1,*
1. Laboratory of Toxicology & Pharmacology, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China
2. Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences and Yunnan provinces,
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
3. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
(Received: November 29, 2009; Accepted: October 28, 2010)
ABSTRACT
Eight phenolic compounds including five glucuronides were isolated from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja, which is used as a source of tea. Their structures were characterized by spectroscopic methods. The results of biological assay showed that compounds 1 and 5 had good activities against HIV-1 induced cytopathic effects in C8166 lymphocyte at non-cytotoxic concentrations, with EC50 values of 31.74 and 10.76 μM, and therapeutic index (TI) values of >13.02 and 25.46, respectively. Relationship between molecular structures and their bioactivities was discussed.
Key words: Cyclocarya paliurus, phenolics, flavonol glucuronides, anti-HIV-1 activity, Juglandaceae